A redesigned Mark X was released on October 19, 2009. Engine options are the 2.5L 4GR-FSE V6 and the 3.5L 2GR-FSE V6 found in the Crown, GS 350 and IS 350 but power was increased from 306 to 318 PS (225 to 234 kW; 302 to 314 bhp). Models available are Standard (250G, 250G Four), Premium and Sports (350S, 250G S). The 250G has all-wheel drive as an option (250G Four).
Changes from the X120 generation include the elimination of the exhaust outlet diffuser, 6-speed automatic for AWD models and a return to the hinge design trunk instead of lift support.
As with the last generation Mark X, Toyota’s in-house tuning company Modellista installed a supercharger on the 3.5L 2GR-FSE motor to create the Mark X +M Super Charger. Power output is 360 PS (265 kW; 355 bhp) and 50.8 kg·m (498.2 N·m; 367.4 lbf·ft). 
The Mark X received a face-lift for the 2012 year model. Featuring redesigned front and rear end treatment. The specifications, cabin and chassis are the same as the 2009–2012 model.